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way 362450  (Pfizer Inc)

 
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    Pfizer Inc way 362450
    Way 362450, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/way 362450/product/Pfizer Inc
    Average 90 stars, based on 1 article reviews
    way 362450 - by Bioz Stars, 2026-02
    90/100 stars

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    BA-centric drug discovery: pharmacological classes, impacted diseases, rationale, and example compounds

    Journal: Signal Transduction and Targeted Therapy

    Article Title: Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

    doi: 10.1038/s41392-024-01811-6

    Figure Lengend Snippet: BA-centric drug discovery: pharmacological classes, impacted diseases, rationale, and example compounds

    Article Snippet: Besides that of GW4064 derivative scaffolds, WAY-362450 (Wyeth Pharmaceuticals which was acquired by Pfizer) is a potent full FXR agonist but is horribly insoluble and has been tested only in mice., In 2003 fexaramine (Salk Institute) was discovered, which exhibited partial gut FXR agonism and no significant hepatic agonism.

    Techniques: Drug discovery, Inhibition, Expressing, Bacteria